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ALAN A. WANDERER, M.D.C
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About the Author

Alan A. Wanderer, M.D. is a graduate of Columbia College of Physicians and Surgeons. His medical training included an internal medicine internship at Bellevue Hospital-Columbia Internal Medical Division, pediatric residency at Cornell Medical School and fellowship in allergy, asthma, and clinical immunology at National Jewish Center, Denver, Colorado. He is board certified by the American Board of Allergy and Immunology and is an active member of the American Academy of Allergy, Asthma and Immunology and the American College of Allergy, Asthma and Immunology. He taught on the faculty of National Jewish Center and is currently a Clinical Professor of Pediatrics and Allergy at the University of Colorado Health Sciences Center. Dr. Wanderer has authored over fifty articles on allergy-clinical immunology subjects, particularly on the subject of urticaria (hives) including chapters in medical textbooks. He is an active lecturer on a variety of allergy/immunology related subjects at medical meetings and university medical schools. Much of his research has concentrated on the mechanisms and therapy of a reproducible type of hives induced by cold, namely acquired cold urticaria. His collaboration with Dr. Hal Hoffman has led to the identification of the gene that is responsible for an inherited cold sensitivity disorder called familial cold auto-inflammatory syndrome. On-going research indicates that the identified gene is involved in important innate immune responses. He was lead author of recently published practice parameter guidelines for the diagnosis and treatment of urticaria and angioedema that was sponsored by the Joint Task Force of the American Academy of Allergy, Asthma and Immunology and the American College of Allergy, Asthma and Immunology. His expertise in these medical conditions is recognized nationally and internationally.

Dr. Wanderer is associated with “Allergy & Asthma Consultants of Montana, LLC” located in Bozeman, MT. He is available to evaluate hives, nasal-sinus symptoms, asthma, food reactions, bee sting sensitivity and drug reactions. Consultation appointments can be scheduled at 1-406-582-1111.

 

ARTICLES BY DR. ALAN WANDERER ON URTICARIA/ANGIOEDEMA

BIBLIOGRAPHY:

TEXTBOOK:

  1. Wanderer AA: Hives: The Road to Diagnosis & Treatment of Urticaria.  Anson Publishing, LLC. 2004.

IN PRESS:

  1. Wanderer AA. Corticosteroid Resistance in Pulmonary Neutrophilic Inflammatory Disorders and Rationale for Adjunct IL-1ß Targeted Therapy. Amer J Resp Cell Mol Biol. 2008; in press.

ARTICLES:

  1. Wanderer AA. IL-1β targeted therapy in severe persistent asthma (SPA) & COPD: Proposed similarities between biphasic pathobiology of SPA/COPD & ischemia-reperfusion injury. IMAJ,  December 2008., special edition on allergy/immunology, as part of December 2008 conjoint conference between ACAAI & Israel Allergy/Immunology Society.
  2. Wanderer AA. Ischemic-Reperfusion Syndromes: Biochemical and immunologic rationale for IL-1 targeted therapy. Clinical Immunology, 2008; 128: 127-132.
  3. Wanderer AA, Hoffman H. Misstatements on cryopyrin-associated periodic fevers. Ann Allergy Asthma Immunol. 2008:101: 111-112.
  4. Hal M. Hoffman, Sanna Rosengren, David L. Boyle, Jae Y. Cho, Jyothi Nayar, James L. Mueller, Justin P. Anderson, Alan A. Wanderer, Gary S. Firestein. Interleukin-1 receptor antagonist prevents cold-associated acute inflammation in familial cold autoinflammatory syndrome. Lancet 2004; 364:1779-85.
  5. Wanderer AA.  A potential new therapy for cold urticaria and chronic idiopathic urticaria. J. Allergy Clin Immunol, 2007, 119: 517-518
  6. Wanderer AA and Hoffman HM : Spectrum of Cold–Induced Urticaria & Urticaria-Like Syndromes. Allergy & Clinical Immunology Clinics of North America. Elsevier-Saunders, Editor: Dreskin S.  Volume 24, Number 2, May 2004.
  7. Hoffman H and Wanderer AA,  Hereditary Urticaria and Angioedema, Marcel Dekker,  Editors: Greaves M & Kaplan A; 2004 and to be published 2009 edition.
  8. Hoffman HM, Gregory SG, Mueller JL, Tresierras M, Broide DH, Wanderer AA, Kolodner RD: Fine structure mapping of C1AS1: identification of an ancestral haplotype and a common FCAS mutation, L353P.Hum Genet 2003 112: 209-16.
  9. Hoffman HM, Wanderer AA, Broide DH: Familial cold autoinflammatory syndrome: phenotype and genotype of an autosomal dominant periodic fever. J Allergy Clin Immunol 2001 Oct; 108.
  10. Wanderer AA, Goodman DL: Practice Parameters Re’ Urticaria and Angioedema for Allergy and Immunology Joint Task Force. . J Allergy Clin Immunol, December Supplement, 2000.
  11. Hoffman HM, Mueller JL, Brodie DH, Wanderer AA, Kolodner RD: Mutation of a new gene encoding a putative pyrin-like protein causes cold autoinflammatory syndrome and Muckle-Wells syndrome. Nature Genetics. 2001., 29: 301-5.
  12. Hoffman HM, Wright FA, Broide DH, Wanderer AA, Kolodner RD: Identification of a Locus on Chromosome 1q44 for Familial Cold Urticaria. Am J. Hum. Genet. 2000 66:1693-8.
  13. Bernstein DI, Berkowitz RB, Chervinsky P, Dvorin DJ, Finn AF, Gross GN, Karetzky M, Kemp JP, LaForce C, Lumry W, Mendelson LM, Nelson H, Pearlman D, Rachelefsky G, Ratner P, Repsher L, Segal AT, Selner JC, Settipane GA, Wanderer A, Cuss FM, Nolop KB, and Harrison JE: Dose-Ranging Study of a New Steroid for Asthma: Mometasone Furoate Dry Powder Inhaler. Accepted to Respiratory Medicine.
  14. Schenkel, EJ, Bronsky EA, Miller SD, Pearlman DS, Rooklin A, Rosen JP, Ruff ME, Skoner DP, Vandewalker ML, Wanderer A, Damaraju CV, De Sapio S, Mesaraini-Wicki, B.: Absence of Growth Retardation in Children with Perennial Allergic Rhinitis Following 1 Year of Treatment with Mometasone Furoate Aqueous Nasal Spray. Pediatrics, 105(2):e22.
  15. Kemp J., Wanderer A., Ramsdel J, Southern D. L., Weiss S., Aaronson D., Grossman J.:  Rapid onset of control with Budesonide Turbuhaler® in patients with mild to moderate asthma.  Annals Allergy,Asthma, &Immunology, 82:463-471,1999.
  16. Thompson, Hannis, Harbeck, Ronald J., Wanderer, Alan A.: Cross Contamination of Blood Cell Unit Samples Associated with Scissors Cutting of Segments. Laboratory Medicine, 1998.
  17. Rosenthal R, Berger W, Bronsky E, Wanderer A, et. al: Tri-Nasal™ Triamcinolone Acetonide Nasal Spray 200 and 400 mcg Qd vs Placebo and Nasacort® Triamcinolone Acetonide Nasal Aerosol 440mcg qd in Patients Suffering from Seasonal Allergic Rhinitis during the Grass Season.  J. Rhinology, November-December 12, No 6, 427-433, 1998.
  18. Corren J, Harris A, Aaronson D, Wanderer A, et. al:  Efficacy and safety of loratadine plus pseudoephedrine in patients with seasonal allergic rhinitis and mild asthma.  J Allergy Clin Immunol, 100: 781-788, 1997.
  19. Israel E, Cohn J, Dub 1, Drazen JM, Wanderer AA, et. al.: Effect of Treatment with Zileuton, a 5-Lipoxygenase Inhibitor, in Patients With Asthma.  JAMA, 275: 931-936, 1996.
  20. Wanderer AA: Spectrum of Cold Urticaria; Allergy Clinics of North America.  Nov. 1995.
  21. Wanderer AA: Urticaria and Angioedema, in Problem-Oriented Medical Diagnosis. 6th ed., H Harold Friedman, 1994.
  22. Wanderer AA: Urticaria and Angioedema, in Problem-Oriented Medical Diagnosis. 5th ed., H Harold Friedman, 1991.
  23. Wanderer AA: Cold urticaria syndromes: Historical background, diagnostic classification, clinical and laboratory characteristics, pathogenesis and management. J Allergy Clin Immunol 85: 965-982, 1990.
  24. Wanderer AA: Systemic cold urticaria.  J Allergy Clin Immunol 87: 137, 1991.
  25. Wanderer AA.  Essential acquired cold urticaria.  J Allergy Clin Immunol 85: 531-532, 1990.
  26. Wanderer AA: Urticaria and Angioedema, in Problem-Oriented Medical Diagnosis. 4th ed., H Harold Friedman, 1987 and 5th ed., H Harold Friedman, 1991.
  27. Wanderer AA, Solomons C: Detection characteristics of a commercially available sulfite detection test (SULFITEST): Problems with decreased sensitivity and false negative reactions.  Annals of Allergy 58: 41-44, 1987.
  28. Wanderer AA, Grandel KE, Wasserman SI, Farr RS: Clinical characteristics of cold-induced systemic reactions in acquired cold urticaria syndromes: Recommendations for prevention of this complication and a proposal for a diagnostic classification of cold urticaria.  J Allergy Clin lmmunol. 78: 417-423, 1986.
  29. Wanderer AA: Cold Urticaria Syndromes: How to diagnose and manage these heterogeneous disorders.  Medical/Scientific Update (National Jewish Center for Immunology and Respiratory Medicine) 5: 1-6, 1986.
  30. Wanderer AA: Update on Cold Urticaria.  New Horizons in Pulmonary and Allergy : 5, number 2,1986.
  31. Grandel KE, Farr RS, Wanderer AA, Eisenstadt TC, Wasserman SI:  The association of platelet activating factor with primary cold urticaria.  N Eng J Med       313: 405-409,1985.
  32. Wanderer AA, Nuss DD, Tormey AD, Giclas PC: Urticarial leukocytoclastic vasculitis with cold urticaria.  Arch Derm 1 1 9:145-1 51, 1983.
  33. Wanderer AA.  Physical Allergy.  In: Bierman W, Pearlman D, eds.  Allergic Diseases of Infancy, Childhood, and Adolescence.  Saunders WB First ed., 447-451, 1980.
  34. Wanderer AA: An allergy to cold.  Hosp Practice 14: 136-137,1979.
  35. Wanderer AA: Recurrent bronchitis.  Hosp Practice 14: 49,54,1979.
  36. Wanderer AA, Flaxer C :Allergy and Immunology.  In: Rakel RE, Conn HF, eds.  Family Practice.  Philadelphia: WB Saunders, Second edition, 1136-1149, 1978.
  37. Wanderer AA, St. Pierre JP, Ellis EF: Primary acquired cold urticaria: Double blind comparative study of treatment with cyproheptadine, chlorpheniramine, and placebo.  Arch Derm 113: 1375-1377, 1977.
  38. Wanderer AA.  Hypersensitivity to physical factors.  In, Gellis SS, Kegan BM, eds.  Current Pediatric Therapy.  WB Saunders, 6th edition, 718, 1973.
  39. Wanderer AA, Pearlman DS: Hypersensitivity to physical factors.  In, Barnett HL, ed.  Pediatrics.  Appleton, Century & Crofts, 15th ed., 487-491, 1972.
  40. Wanderer AA, Ellis EF: Treatment of cold urticaria with cyproheptadine.  J Allergy 48: 366-371, 1971.
  41. Wanderer AA, Maselli R, Ellis EF, Ishizaka K: Immunologic characterization of serum factors responsible for cold urticaria.  J Allergy 48: 1 3-22, 1971.
  42. Wanderer AA, Ellis EF: Late-onset hypogammaglobulinemia with cellular immune deficiency.  J Pediatrics 78: 278-284, 1971.
  43. Wanderer AA, Ellis EF, Goltz RW, Cotton EK: Tracheobronchiomegaly and acquired cutis laxa in a child.  Pediatrics 44: 709-71 5, 1969.

ABSTRACTS:

  • Hoffman H, Broide D, Wanderer AA. The genetic and molecular basis of Familial Cold Urticaria. Aspen Allergy Conference, 17th Annual Meeting, July, 1999.
  • Adelglass JM, Banov C, LaForce C, Wanderer AA, et. al.: Randomized, double-blind, parallel comparison of Atrovent® nasal spray 0.03% versus placebo Administered twice a day in patients with allergic (APR) or nonallergic (NAPR) perennial rhinitis.  American College of Allergy, Asthma and Immunology meeting, 1995.
  • Noonan MJ, Wanderer AA, et. al.: A multicenter, double-blind, randomized, parallel-group study comparing the clinical effect of three oral doses of MK0476 and placebo in adult patients with stable, moderate asthma.  European Respiratory Society meeting, 1995. Printed in Eur Respir;11:1232-1239
  • Storms W, Wanderer AA, et. al.: Treating Asthma by blocking the lipoxygenase pathway.  American Thoracic Society presentation at the International Conference, 1995.
  • Israel E, Cohn J, Dube L, Drazen JM and the Zileuton Clinical Trial Group (Wanderer AA et al): The Effect of Three Months of Treatment with a 5-Lipoxygenase Inhibitor in Patients with Asthma.  Submitted to JAMA, 1995.
  • Sperling M, Phillips S, Wanderer AA, et. al.: Treatment of Condylomata Acuminata with Intralesional Fluorouracil/Epinephrine Injectable Gel Results in High Response Rates: A Phase III Clinical Study.  AAD meeting 1995.
  • Swinehart JM, Sperling M, Phillips S, Kraus S, Gordon S, McCarty JM, Webster GF, Skinner R, Korey A, Orenberg EK, Wanderer AA, et. al.  Poster, 24th Annual Meeting of the European Society for Dermatological Research, Vienna, Austria, September, 1994.
  • Ostrom N, Welch M, Morris R, Rosen J, Wanderer AA, Dockhorn R, Tinkelman D, Vandewalker M, Ziering W: Evaluation of Ebastine (Eba), a new non-sedating antihistamine in children with seasonal allergic rhinitis (SAR).  American Academy of Allergy and Immunology Annual Meeting; November, 1993.
  • Monroe E, Bernstein D,Bronsky E, Hanifin J, Prenner B, Schoenwetter W, Spector S, Stafford C, Stroh J, Wanderer A, McNutt B, Huster W: A double blind, randomized placebo controlled, parallel study comparing the safety and efficacy of terfenadine 60 mg bid to hydroxyzine 25 mg qid administered for 6 to 12 weeks in the treatment of chronic idiopathic urticaria.  American Academy of Allergy & Immunology, 48th Annual Meeting, March, 1992.
  • Margolskee D, Friedman B, Williams W, Noonan M, Altman L, Bone R, Dockhorn R, Ellis E, Eschenbacher W, Findlay S, Grant J, Grossman J, Hendeles L, Israel E, Kemp J, Nelson H, Pearlman D, Stricker W, Tinkelman D, Townley R, Vandewalker M, Wanderer A, Weisberg S, Winder J: The therapeutic effects of MK-0679, a potent and selective leukotriene receptor antagonist in patients with chronic asthma.  To be presented at International Conference on Prostaglandins and Related Compounds, Montreal, July, 1992
  • Tonnesen MG, Clark RAF, Siegal SL, Reed BR, Capin L, Wanderer AA: Cyclic endothelial cell injury and chronic blood vessel wall alterations in familial cold urticaria.  Third Annual Aspen Allergy Conf, July, 1985.
  • Tonnesen MG, Clark RAF, Siegal SL, Reed BR, Capin L, Wanderer AA: Cyclic endothelial cell injury and chronic blood vessel wall alterations in familial cold urticaria.  Clin Res 33: 690A, 1985.
  • Wanderer AA, Farr RS, Grandel KE, Wasserman SI: Detection and management of cold urticaria patients at high risk for cold-induced systemic reactions.  American Acad Allergy & Immunology, March, 1985.
  • Grandel KE, Eisenstadt TC, Wanderer AA, Wasserman SI, Farr RS: A platelet activating factor-like lipid in the plasma of patients during the induction of acquired cold urticaria.  Fed Proc 43: 1925, 1984.
  • Wanderer AA: Treatment of cold sensitivity syndromes with urticaria and/ or angioedema.  Second Annual Aspen Allergy Conf.  N Eng Res Allergy Proc 6:(3):            272-273, 1985.
  • Wanderer AA, Ellis EF, Raffa JB, Angleton GM: Double antigen stimulation of histamine release from human leukocytes.  J Allergy 45: 127, 1970.
  • Solomons CC, Cotton EK, Folkestad DP, O'Mara OP, Wanderer AA: The effect of L-arginine administration on pulmonary function in patients with cystic fibrosis.  Cystic Fibrosis Club Abstracts, Ninth Annual Meeting, 1969.

 
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